New Barbie dolls are modeled after the spring break antics of Girls Gone Wild; Crossroads and A Walk to Remember merge in a new film; Dot (Weir) is a guest on Oprah; DMX gets advice from his mother (Spears); Stuart Larkin (Mc Donald) gets a new bicycle; Adam Carolla and Jimmy Kimmel play figure-skating color commentators; a vodka commercial's promise not to glamorize alcohol for teenage audiences is broken; George W.Bush (Sasso) summons sorcerers Melissa Joan Hart, Jeannie, and Glinda to solve world problems.
Brian Mc Fayden hosts the latest Family Values Tour event; a parody of 7th Heaven; Noah Slotnick (Caliendo) and supermodel Amber Valletta (Fiore) star in a new sitcom called Yes, Noah; Marvin Tikvah (Mc Donald) buys a Miata for his bratty daughter (Borstein); Randy Newman (Sasso) records an album of duets with various singers; a store owner (Sasso) holds a going-out-of-business special; a washed-up actress (Weir) teaches a drama class; a Fox reporter (played by Mad TV writer Michael Hitchcock) asks Mad TV audience members what they think about the show.
Triple H competes against Stone Cold Steve Austin (Sasso) to determine who will appear on Mad TV; a high school wrestler goes against an overconfident lightweight (Lee); a man (Mc Donald) is forced to shave and change his clothes after neighbors repeatedly mistake him for Osama bin Laden; a parody of Destiny's Child's cover of "Emotion" centered on Beyonce Knowles (Wilson) stealing the spotlight; Michael Jordan (Spears) is hounded by news reporters for his poor performance on the court; Method Man and Redman appear on Real Motherfucking Talk; Fightin' Ron (Mc Donald) enters anger management; Dorothy Lanier (Weir) prepares for her role in a commercial. Bush (Sasso) and Colin Powell (Spears) rap about world events; Santa's elves are worried that envelopes addressed to the North Pole might contain anthrax; Kenny Rogers (Sasso) and his son Benny (Caliendo) wish the audience a Merry Christmas; Trina Moss (Collins) may give birth to a newborn baby in a manger; Destiny's Child and MC Hammer (Spears) send messages to the troops in Iraq; Will Sasso and Alex Borstein conduct interviews at the VH-1 Music Awards; a woman (Wilson) regrets begging Jesus (Mc Donald) to spare her husband's life.
A parody of "I'm Not a Girl, Not Yet a Woman" features clichéd visual sexual metaphors and a now-legal Britney Spears (Melean); '70s sex ed.
film on what to do if you have VD; celebrities discuss marriage in the modern age on Politically Incorrect; Dot (Weir) searches for her glove in a laundromat; the cast of Jackass joins Kenny Rogers (Sasso) in a series of outrageous stunts on Kenny Rogers' Jackass; a quartet of prisoners (Caliendo, Sasso, Spears, Killam) sings a ditty about recycling at a school.
After Nicole Sullivan left at the end of season six, Debra Wilson was the last remaining member of the original cast.
Season 6 featured players Andrew Daly and Stephnie Weir were promoted to repertory players.
Joining the cast this season were Frank Caliendo, Kathryn Fiore, Jill-Michele Meleán, Taran Killam (the youngest Mad TV cast member at 19 years old, the only Mad TV cast member to get his start on a children's television show [Nickelodeon's The Amanda Show] and, later, the second MADtv cast member to be hired as a Saturday Night Live cast member), and Bobby Lee (the first Asian-American cast member).
Guest Michelle Trachtenberg appeared in a parody of Buffy the Vampire Slayer with Alex Borstein's Ms. Trachtenberg, who actually appears in "Buffy", was nominated for a Young Artist Award for Best Performance in a TV Comedy Series for her Mad TV stint. Fox, Frankie Muniz, Amanda Bynes, *NSYNC members Lance Bass and Joey Fatone, wrestlers Triple H and Stone Cold Steve Austin, The Man Show hosts Adam Carolla and Jimmy Kimmel, and several hip-hop artists (including DMX, Ja Rule, Insane Clown Posse, Master P., Method Man, Redman, and the RZA).
NSYNC sings about irritable bowel syndrome; Lorraine Swanson (Collins) is a contestant on The Price is Right; Oprah (Wilson) and Dr.
Phil (Mc Donald) field questions from the audience; Michelle Trachtenberg reprises her role as Dawn Summers from Buffy the Vampire Slayer; John Madden (Caliendo) reports from Iraq; on The Weakest Link, D-list celebrities play for their charities; a parody of Leave It to Beaver featuring Blink-182 as troublemaking kids from the 1950s; Will Sasso and Alex Borstein conduct interviews at the premiere for Harry Potter and the Sorcerer's Stone.
Mofaz (Mc Donald) makes other psychotherapy patients feel better about themselves; Public Schoolhouse Rock centers on behavior-modifying drugs for children; an office worker (Sasso) fakes mental retardation to annoy his coworker (Killam); a yoga teacher (Mc Donald) demonstrates creepy yoga poses and techniques; a man (Killam) inspects guitars for sale; after winning an award, James Gandolfini (Sasso) goes on a rampage when he can't find a way off the stage; an old, overweight man (Spears) complains to his neighbors that he passed out while masturbating.